1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a novel psychedelic substance of the lysergamide class. It is structurally related to LSD and other novel lysergamides like 1cP-LSD, 1B-LSD, and 1V-LSD. It is thought to produce its effects by stimulating serotonin receptors in the brain, although the precise mechanism is not known. Buy 1P-LSD online Liquid 1p lsd for sale in USA Buy 1p LSD online with bitcoin from BTC Meth Plug at very affordable. Buy pure 1P LSD online
1P-LSD has been sold online as a research chemical (also called “designer drug”) since 2015, but the original synthesis date of 1P-LSD is unknown furthermore. Unlike most research chemicals, it has no documented record in the research literature before its emergence on the online research chemical market in 2015.
It was marketed as a legal alternative to LSD alongside other novel lysergamides like Buy ALD-52 online Australia, ETH-LAD, and Buy AL-LAD online Australia. In 2019, it became part of a group of molecules studied by the French laboratory Caulredaitens.
Liquid 1p lsd for sale in USA
Subjective effects include geometric visual hallucinations, time distortion, enhanced introspection, conceptual thinking, euphoria, and ego loss furthermore. User reports indicate that the subjective effects of 1P-LSD are extremely similar to those of LSD. This predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. Its classical psychedelic effects and favorable tolerability has led it to become popular among novel substance users who use it interchangeably with LSD.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD furthermore. It is highly advised to use harm reduction practices practices if using this substance.
1P-LSD first appeared on the online research chemical market in January 2015. Buy 1P-LSD online Australia is a semisynthetic compound of the lysergamide family. Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group.
Buy 1p LSD online with bitcoin
1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location furthermore. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group.
Based on its structural similarity to LSD, 1P-LSD likely acts as a partial agonist at the 5-HT2A receptor.
1P-LSD also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine furthermore. However, there is currently no experimental data to support these claims. Otherwise, it is possible that 1P-LSD possesses intrinsic activity. Buy 1P-LSD online Liquid 1p lsd for sale in USA Buy 1p LSD online with bitcoin from BTC Meth Plug at very affordable. Buy pure 1P LSD online
Prior to the publishing of the above-cited research, medicinal chemist and psychedelics researcher David E. Nichols reportedly commented on the potential 1P-LSD serotonin receptor binding dynamics in private correspondence:
|“||I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don’t know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don’t know the answer to that. The compound would not be active as the N-propionyl however. The way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won’t fit into the receptor.||”|
|— David E. Nichols.|
The study also found that LSD’s bioavailability after oral ingestion of 1P-LSD was close to 100%.